NMR/MRI
In partnership with the group of Matthew Rosen, we developed an open-access, low-magnetic-field human MRI instrument, which allows studies of:
(i) traumatic brain injury (TBI)
(ii) molecular imaging using hyperpolarized nanoparticles and other media created by dynamic nuclear polarization (DNP)
(iii) pulmonary physiology using inhaled hyperpolarized noble gas (3He and 129Xe)
We also investigate the creation and application of novel spin states in biomolecules, such as long-lived nuclear spin singlet states and coherences between singlet and triplet states.
High-Resolution NMR Spectroscopy Using Quantum Diamond Sensors
Left: NV ensemble in diamond serves as a high-spectral-resolution NMR sensor for samples at the scale of a single cell (~10 microns). Right: NV-NMR spectrum of xylene provides chemical information at the micron-scale.
Publications
- Impedance-Tuned Microwave Loop for Fast, Homogeneous Rabi Oscillations of a Dense Ensemble of NV-Diamond Electronic Spins. . Nano Letters 25, 15566-15571 (2025). link PDF supplement arXiv
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- Prospects for Ultralow-Mass Nuclear Magnetic Resonance using Spin Defects in Hexagonal Boron Nitride. . arXiv:2505.00383v1 (2025). PDF arXiv
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- Quantum diamond microscope for narrowband magnetic imaging with high spatial and spectral resolution. . Phys. Rev. Appl. 22, 054050 (2024). link PDF arXiv
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- Roadmap on nanoscale magnetic resonance imaging. . Nanotechnology 35, 412001 (2024). link PDF arXiv
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- Nutation-based longitudinal-sensing protocols for high-field NMR with nitrogen-vacancy centers in diamond. . Phys. Rev. Appl. 22, 024043 (2024). link PDF arXiv
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- High-resolution magnetic resonance spectroscopy using a solid-state spin sensor. . Nature 555, 351–354 (2018). link PDF supplement arXiv
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- Mapping the microscale origins of magnetic resonance image contrast with subcellular diamond magnetometry. . Nature Communications 9, 131 (2018). link PDF arXiv
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- Nanodiamond-enhanced MRI via in situ hyperpolarization. . Nature Communications 8, 15118 (2017). link PDF supplement
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- Nuclear magnetic resonance detection and spectroscopy of single proteins using quantum logic. . Science 351, 836–841 (2016). link PDF supplement
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- NMR technique for determining the depth of shallow nitrogen-vacancy centers in diamond. . Physical Review B 93, 045425 (2016). link PDF arXiv
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- Probing scalar coupling differences via long-lived singlet states. . Journal of Magnetic Resonance 262, 42–49 (2016). link PDF supplement arXiv
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- Nanoscale NMR spectroscopy and imaging of multiple nuclear species. . Nature Nanotechnology 10, 129–134 (2015). link PDF supplement arXiv
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- Magnetic Resonance Detection of Individual Proton Spins Using Quantum Reporters. . Physical Review Letters 113, 197601 (2014). link PDF
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- Subnanometre resolution in three-dimensional magnetic resonance imaging of individual dark spins. . Nature Nanotechnology 9, 279–284 (2014). link PDF arXiv
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- Dependence of nuclear spin singlet lifetimes on RF spin-locking power. . Journal of Magnetic Resonance 218, 5–10 (2012). link PDF supplement arXiv
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- Quantum control of proximal spins using nanoscale magnetic resonance imaging. . Nature Physics 7, 687–692 (2011). link PDF supplement arXiv
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- Silicon Nanoparticles as Hyperpolarized Magnetic Resonance Imaging Agents. . ACS Nano 3, 4003–4008 (2009). link PDF supplement arXiv
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- An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging. . Journal of Magnetic Resonance 193, 274–285 (2008). link PDF
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- Posture-Dependent Human 3He Lung Imaging in an Open Access MRI System: Initial Results. . Academic Radiology 15, 728–739 (2008). link PDF
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- NMR measurements of grain and gas motion in a gas-fluidized granular bed. . Granular Matter 9, 331–335 (2007). link PDF
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- Understanding the breakdown of Fourier's law in granular fluids. . American Journal of Physics 75, 754–757 (2007). link PDF
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- Noninvasive Measurements of Gas Exchange in a Three-Dimensional Fluidized Bed by Hyperpolarized 129Xe NMR. . Applied Magnetic Resonance 32, 93–112 (2007). link PDF
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- Diffusion NMR methods applied to xenon gas for materials study. . Magnetic Resonance in Chemistry 40, S29–S39 (2002). link PDF
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- The Narrow Pulse Approximation and Long Length Scale Determination in Xenon Gas Diffusion NMR Studies of Model Porous Media. . Journal of Magnetic Resonance 156, 202–212 (2002). link PDF arXiv
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- Novel MRI applications of laser-polarized noble gases. . Applied Magnetic Resonance 22, 159 (2002). link
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- Measuring surface-area-to-volume ratios in soft porous materials using laser-polarized xenon interphase exchange nuclear magnetic resonance. . Journal of Physics. Condensed Matter 14, L297–304 (2002). link PDF arXiv
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- Phase coherence and control of stored photonic information. . Physical Review A 65, 031802 (2002). link PDF arXiv
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- Measurements of Grain Motion in a Dense, Three-Dimensional Granular Fluid. . Physical Review Letters 88, 044301 (2002). link PDF arXiv
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- A System for Low Field Imaging of Laser-Polarized Noble Gas. . Journal of Magnetic Resonance 141, 217–227 (1999). link PDF
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- Probing Porous Media with Gas Diffusion NMR. . Physical Review Letters 83, 3324–3327 (1999). link PDF
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- Single-Shot Diffusion Measurement in Laser-Polarized Gas. . Journal of Magnetic Resonance 140, 320–324 (1999). link PDF
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- Magnetic resonance imaging of laser polarized liquid xenon. . Physical Review E 59, 1785–1788 (1999). link PDF
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- Gradient-echo imaging considerations for hyperpolarized 129Xe MR. . Journal of Magnetic Resonance. Series B 113, 179–183 (1996). PDF
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- Determinants of tissue delivery for 129Xe magnetic resonance in humans. . Magnetic Resonance in Medicine 36, 340–344 (1996). link
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- Temporal dynamics of hyperpolarized 129Xe resonances in living rats. . Journal of Magnetic Resonance. Series B 111, 300–304 (1996). link PDF
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- Hyperpolarized 129Xe MR imaging of the oral cavity. . Journal of Magnetic Resonance. Series B 111, 204–207 (1996). link PDF
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